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Anthropic says Claude helped identify novel enzyme system with CRISPR-like repeats

Anthropic says Claude helped identify an uncharacterized enzyme system in bacteriophages with DNA repeats reminiscent of CRISPR. The company says ART’s function is not yet known. ☀ Claude searched more than 200,000 enzyme sequences, and researchers tested candidates in a lab. · ☀ Initial experiments found short RNA molecules associated with the ART array. · ☀ The results are preliminary and do not establish an available gene-editing tool.

Illustrative image of a bacteriophage, DNA helix and enzyme structure representing preliminary ART enzyme research.
ILLUSTRATIVE

Anthropic says its Claude model helped identify a previously uncharacterized enzyme system in bacteriophages by searching DNA databases. The company named the system array-associated reverse transcriptases (ART), describing its DNA repeats as reminiscent of CRISPR.

According to Anthropic, Claude examined more than 200,000 reverse transcriptases, and researchers tested candidates in a laboratory. The company’s initial experiments found that the ART array produces short RNA molecules. The system’s underlying function remains unknown.

The finding does not mean researchers have discovered a gene-editing tool ready for use. The results are early and are described in a company technical preprint; experiments to understand how ART works are continuing.

Sources: Anthropic research announcement; Reuters.

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